Multiple organ dysfunction syndrome?

summary

Multiple organ dysfunction syndrome (MODS) refers to a clinical syndrome in which two or more organs or systems are dysfunctional at the same time or in sequence in the process of acute diseases such as severe trauma, shock, infection and major surgery, so that the internal environment can not be maintained.

Multiple organ dysfunction syndrome?

Mods may occur in any disease causing systemic inflammatory response. Surgical diseases are common in the following aspects: 1. Sepsis caused by various surgical infections. 2. Blood loss and water shortage caused by severe trauma, burn or major operation. 3. Various causes lead to ischemia-reperfusion injury of limbs, large area of tissues or organs. 4. Shock of various causes, cardiac arrest and respiratory arrest after resuscitation. 5. Blood transfusion, infusion, medicine or mechanical ventilation. 6. Acute abdomen with organ necrosis or infection. 7. Patients with some diseases are more prone to mods, such as chronic diseases of heart, liver and kidney.

There are two types of clinical processes of MODS. 1. One stage rapid onset refers to the simultaneous dysfunction of two or more organ systems 24 hours after the onset of primary acute disease. 2. Second stage delayed type, second stage delayed type is the dysfunction of an important system or organ, often cardiovascular, renal or pulmonary dysfunction, after a period of approximately stable period, and then multiple organ system dysfunction.

In the final analysis, multiple organ dysfunction syndrome (MODS) is caused by the further deterioration of various primary diseases. Therefore, the principle of treatment is to carry out multiple organ function support therapy on the basis of active treatment of primary diseases, improve organ microcirculation ischemia and hypoxia, reverse shock and prognosis. Its supportive treatment involves almost all organs or systems of the whole body. They include: hemodynamic support, respiratory support, focus control, use of antibiotics, renal replacement therapy, anticoagulant therapy, nutritional support, appropriate use of sedatives / anesthetics, immune conditioning, and other supportive treatments. In this regard, rich experience has been accumulated in the past decades.

matters needing attention

In the treatment of MODS, medical workers are still tirelessly exploring, hoping to find a way to reverse the disease. Mods is essentially a multiple organ dysfunction caused by trauma, infection, ischemia and other primary diseases. The principle of treatment is to carry out comprehensive treatment such as organ support, anti infection, nutrition and immune regulation on the premise of treating primary diseases.