What is hemochromatosis

summary

My grandmother has always had diabetes, and her heart is not very good. Recently, I found that her skin is dark yellow, and she has little strength. She went to the hospital for examination and showed hepatomegaly. The doctor said that she may have hemochromatosis. Now let's talk about what hemochromatosis is.

What is hemochromatosis

First: hemochromatosis (HC), also known as hereditary hemochromatosis (HHC, Hh), is a common chronic iron overload disease, which is an autosomal recessive genetic disease. Due to the improper increase of intestinal iron absorption, excessive iron is stored in the liver, heart, pancreas and other parenchymal cells, leading to tissue and organ degeneration and diffuse fibrosis, metabolic and functional disorders.

Second: hemochromatosis is also known as primary hemochromatosis, hemochromatosis or primary iron excess. Its basic pathogenesis is that excessive iron deposition in tissues and organs leads to cytopathy, usually involving the liver, pancreas and heart, which is manifested as severe complications such as cirrhosis, diabetes and heart disease.

Third: hemochromatosis is a rare congenital metabolic defect. It is caused by excessive iron deposition in organs and tissues, causing different degrees of stromal cell destruction, fibrous tissue hyperplasia and organ dysfunction. The clinical manifestations include liver cirrhosis, diabetes, skin pigmentation, endocrine disorders, heart and joint diseases.

matters needing attention

For patients with hemochromatosis, bloodletting is the simplest iron excretion therapy, and can improve the survival rate, but can not change the incidence of hepatocellular carcinoma. And patients should pay attention to low iron diet, control of iron intake is the main treatment of the disease.