How does nasopharyngeal carcinoma form

Update Date: 2021-04-12 Source: Network

summary

I don't know what happened these two days? Frequent runny nose, headache, go to the hospital examination, the result is got nasopharyngeal carcinoma, after the expert's explanation, understand the relevant knowledge of nasopharyngeal carcinoma, we learn how to form nasopharyngeal carcinoma.

How does nasopharyngeal carcinoma form

The first reason is: (1) family aggregation: many NPC patients have family history of cancer. Nasopharyngeal carcinoma has vertical and horizontal familial tendency. (2) race susceptibility: nasopharyngeal carcinoma is mainly seen in yellow race, rarely in white race. The incidence rate is high, and people who migrate to other places (or overseas Chinese) are still very high incidence rate. (3) regional concentration: nasopharyngeal carcinoma mainly occurs in five provinces in southern China, namely Guangdong, Guangxi, Hunan, Fujian and Jiangxi, accounting for the first place of head and neck cancer. Southeast Asian countries are also high risk areas. "

Reason 2: susceptible genes: in recent years, molecular genetic studies have found that chromosome 1, 3, 11, 12 and 17 are the main chromosomal changes in nasopharyngeal carcinoma cells. The discovery of loss of heterozygosity regions (1P, 9p, 9q, 11q, 13q, 14q and 16q) in nasopharyngeal carcinoma cells may indicate that there are multiple tumor suppressor gene mutations in the occurrence and development of nasopharyngeal carcinoma.

The third reason is that the residents in the high incidence area are fond of local salted fish, salted meat and pickles. The content of nitrite in these foods is very high, and there is a certain amount of nitrosamines and many kinds of compounds.

matters needing attention

Radiotherapy is always the first choice for nasopharyngeal carcinoma. The 5-year survival rate is about 45%. Chemotherapy was used after radiotherapy to improve the curative effect and reduce the radiation reaction. If the tumor recurres after radiotherapy or is not sensitive or even ineffective to radiotherapy, surgery can be used. At present, the recovery rate of nasopharyngeal carcinoma is still very high.