Can hypertensive nephropathy be cured

summary

Ten years ago, he was diagnosed with hypertensive nephropathy, hydronephrosis, poor renal function and creatinine 271. For patients with this disease should be treated as soon as possible, I will tell you about the problem of hypertensive nephropathy can be cured.

Can hypertensive nephropathy be cured

First, when renal parenchyma or renal vascular lesions occur in the kidney, it often leads to the reduction of the fixation of renal blood perfusion, leading to renal ischemia and hypoxia. At this time, the kidney can secrete a variety of substances that cause the rise of blood pressure, the most important of which is a large number of renin secreted by the paraglomerular cells. Renin is a kind of hydrolytic protease. After entering the blood circulation, renin combines with α 2 globulin released from liver to form angiotensin I (10 peptide), without pressor effect.

The second is that angiotensin I, under the action of angiotensin converting enzyme, takes off two amino acids to form angiotensin II (8 peptide) with strong biological activity through pulmonary circulation, and further splits to form a small amount of angiotensin III (7 peptide). Angiotensin II can make the small arteries around strong contraction and heart beat increased, so that blood pressure increased.

Third, its pressor effect is 15-25 times stronger than that of norepinephrine. In addition, angiotensin II can also act on the adrenal cortex, promote aldosterone secretion, increase sodium and water retention, and increase blood vessel sensitivity to catecholamine and angiotensin II * hormones. Angiotensin II increases blood pressure, which in turn aggravates arterial spasm, renal ischemia and hypoxia, and decreases the production of antihypertensive substances such as bradykinin and prostaglandin in the kidney, which interact with each other and make blood pressure rise continuously.

matters needing attention

It is very important to take good care of the patients with hypertension. At the same time of medication, it is supplemented by food regulation. Pay attention to diet, low salt (5 grams per day), low animal fat. Obesity in patients with high blood pressure and coronary heart disease, due to excessive fat in the body, will oppress the heart and increase the burden on the heart.