What disease is blood creatinine tall

summary

Grandma is not very well during this period of time. My mother took grandma to the hospital for examination. When I came back, my mother told me that this time Grandma had a high serum creatinine, and I didn't know what the disease was. After checking a lot of information on the Internet, I understood what high serum creatinine was. Now let me talk to you about the disease of high serum creatinine.

What disease is blood creatinine tall

First: high creatinine means that the creatinine value is higher than the normal value. Creatinine includes blood creatinine and urine creatinine, but blood creatinine is more significant in measuring renal function. So high creatinine generally refers to high blood creatinine. The normal value of serum creatinine is different in different hospitals. Generally speaking, the normal value of serum creatinine is 44-133 μ mol / L. when the serum creatinine exceeds 133 μ mol / L, it means kidney damage, renal insufficiency and renal failure. (more than 133 μ mol / l was inflammatory injury stage, 186 μ mol / l was renal function injury stage, 451 μ mol / l was renal failure stage).

Second: creatinine is the product of human muscle metabolism. In human muscle, creatine mainly forms creatinine slowly through irreversible non enzymatic dehydration reaction, which is then released into the blood and excreted with urine. Therefore, the reason why serum creatinine is high is closely related to the total amount of muscle in the body and is not easily affected by diet. Creatinine is a small molecule substance, which can be filtered through the glomerulus. It is rarely absorbed again in the renal tubules. The daily creatinine produced in the body is almost completely excreted with urine, and is generally not affected by urine volume.

Third: it is not completely consistent with creatinine clearance rate, creatinine clearance rate is more sensitive than serum creatinine. In the early stage of renal dysfunction (compensatory phase), creatinine clearance rate decreased while serum creatinine was normal. When glomerular filtration rate drops to more than 50% of normal, serum creatinine begins to increase rapidly. Therefore, when serum creatinine is significantly higher than normal, it often indicates that renal function has been seriously damaged. Because creatinine clearance rate is also affected by glomerular concentration function, in the case of impaired renal concentration function, serum creatinine is the most reliable indicator of glomerular function. The serum creatinine was 53-106 gmol / L in male and 44.2-97.2 gmol / L in female.

matters needing attention

Life should pay attention to rest, not too tired, resulting in high serum creatinine. People with kidney disease or other diseases should pay attention to the changes of their own conditions, pay attention to maintenance, in order to prevent infection. If you feel unwell, you should go to the hospital for examination in time, find the cause of disease, and treat it as soon as possible, so that the disease can be controlled. High blood creatinine, high blood pressure or kidney disease.