What is fibrinogen high?

Update Date: 2021-10-15 Source: Network

summary

Fibrinogen (also known as blood fibrinogen) is a kind of protein, which can be dissolved in water. It is a kind of protein with coagulation function synthesized by the liver. It is an important substance in the process of coagulation and thrombosis. What is fibrinogen high? Next, I'd like to share my views with you.

What is fibrinogen high?

Fibrinogen is a protein with coagulation function, which is mainly synthesized by hepatocytes. It is the most abundant coagulation factor in plasma. The molecular weight of fibrinogen is about 340 kDa, which is a triple sphere α、β、γ There are three pairs of different polypeptide chains, the two ends of which are D region, and the middle is e region α The helix is connected to the peptide chain.

Fibrinogen is an important substrate of thrombosis, which is involved in the key steps of thrombosis. Fibrinogen forms fibrin monomer under the action of coagulation factors such as thrombin, FX Ⅲ A and Ca2 +, and covalently combines with each other to form fibrin polymer α The stable fibrin network was formed by covalent cross-linking of cross-linked chains, which eventually netted red blood cells (RBC), platelets (PLT), and platelets α 2-antithrombin（ α 2-AP) and other components form stable thrombus structure.

Platelet rupture, will release clotting enzyme, under the action of calcium ion, catalyzing prothrombin into thrombin, thrombin in plasma fibrinogen which can be water-soluble coagulation into insoluble fibrin, fibrin kink other blood cells into clusters, coagulation into blood clots. Fibrinogen (factor I) is a glycoprotein circulating in the blood of vertebrates.

matters needing attention

Don't eat too much fat, especially things with a lot of saturated fatty acids, such as fatty meat, viscera and foods with high cholesterol. Try to reduce them as much as possible. In addition, we need to maintain a good mood, exercise properly, lose weight and so on. If these methods can't make blood lipid return to normal, we have to consider using drugs. Statins are commonly used.