Can primary bone lymphoma be cured?
summary
Primary bone lymphoma (PBL) is a kind of lymphoma whose lesions are limited to bone system or surrounding soft tissue infiltration, but without systemic symptoms. This disease is rare, accounting for only 5% of extranodal lymphomas and 7% of primary bone tumors. Let's share my experience with you.
Can primary bone lymphoma be cured?
Radiotherapy refers to the use of radiation on the tumor and surrounding tissues to achieve clinical remission of killing tumor cells. Many studies have shown that radiotherapy has certain curative effect on primary bone lymphoma.
After radiotherapy, the 5-year and 10-year survival rates of patients with single bone lesion were 58% and 53%, respectively; The 5-year and 10-year survival rates of patients with multiple bone lesions were 42% and 35%, respectively; The 5-year and 10-year survival rates of patients with soft tissue lesions were 22% and 13% respectively. It can be seen that MRI is helpful for judging the therapeutic effect of primary bone lymphoma.
According to a number of experiments, the dose and course of radiotherapy have a certain impact on the curative effect of primary bone lymphoma. For example, the clinical remission rate of large dose and multiple radiotherapy is slightly higher. However, a number of clinical experimental studies show that there are still many patients with recurrence or systemic metastasis after radiotherapy, and the remission rate is only about 50%. The extensive use of chemotherapy in patients with systemic lymphoma makes some scholars use chemotherapy in the treatment of primary bone lymphoma and also obtain some successful experience.
matters needing attention
The prognosis of primary bone lymphoma is mainly related to the histological type of lymphoma, lesion range, age and other factors. The prognosis of schizocytic is better, and the prognosis of non schizocytic disseminated or multiple is the worst. In addition, age, LDH and ECoG index can be used to evaluate and estimate the prognosis.
