How is proteinuria plus going on

Update Date: 2022-05-01 Source: Network

summary

In patients with minimal change nephropathy, mild mesangial proliferative glomerulonephritis, partial membranous nephropathy, early pathological membranous proliferative glomerulonephritis and focal segmental sclerosing glomerulonephritis, most of them showed selective proteinuria, indicating that the damage of glomerular filtration membrane (glomerular filtration membrane) was mild. Then some patients put forward how the urinary protein plus sign is going on.

How is proteinuria plus going on

Reason 1: mesangial toxicity of proteinuria: in the model of renal failure, the accumulation of serum protein in glomerular mesangium can be observed. The accumulation of these macromolecular substances in mesangial area can cause mesangial cell damage and proliferation, and increase the synthesis of mesangial matrix, resulting in glomerulosclerosis.

Reason 2: the toxic effect of proteinuria on proximal convoluted tubular cells: when proteinuria occurs, the amount of protein entering the epithelial cells of renal tubules increases, which increases the activity of lysosomes, suggesting that protein causes lysosomes to overflow into the cytoplasm of tubular cells, and subsequent cell damage can stimulate inflammation and scar formation.

The third reason: the biological changes of tubular cells caused by proteinuria: many kidney diseases with proteinuria have excessive cell proliferation, which represents a non adaptive response and leads to renal failure. More and more evidences show that proteins can directly regulate the function of tubular cells, change their growth characteristics and the phenotypic expression of cytokines and matrix proteins, which can lead to the release of PDGF, FN and MCP-1 from the basal side of tubular cells and induce fibrosis.

matters needing attention

Warm reminder: patients usually want to breathe more fresh air, keep physical and mental health, can also do more exercise, this can not only enhance the physique, but also can improve the body's immunity, it is suggested that patients should go to the local regular three a hospital to do a comprehensive examination, according to the doctor's guidance to regulate medication.