What is isoproterenol?

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Isoproterenol has an effect on blood pressure, so how does it affect it? I think a lot of friends want to know more about it. I know that you must very much hope to get a lot of useful systems from the general hospital. Then how many drops does one accessory kidney have?, Today I'd like to share this with you.

What is isoproterenol?

First, when the general dose of isoproterenol is infused intravenously, the systolic blood pressure increases due to the increase of cardiac output, while the arteriole dilates, the peripheral vascular resistance decreases, and the diastolic blood pressure decreases, resulting in the increase of pulse pressure; High dose can also make the vein strongly dilate, reduce the effective blood volume, reduce the return blood volume and cardiac output, resulting in the decrease of blood pressure. At this time, both systolic and diastolic blood pressure decrease. Dobutamine has a strong positive inotropic effect, which increases cardiac output and systolic blood pressure. Because dobutamine is very sensitive to α 1 and β The receptor had little effect on diastolic blood pressure. If the dosage is too large or the intravenous drip is too fast, the heart rate will increase and the blood pressure will rise.

Second: pharmacodynamics: the main motivation β Receptors, right β 1 and β 2 receptor selectivity is very low α The receptor had little effect. ① Bronchiectasis: acts on the bronchi β 2 adrenoceptors, relax bronchial smooth muscle, inhibit the release of histamine and other mediators. ② Excitement β 1 adrenoceptor, increase heart rate, enhance myocardial contractility, increase the conduction velocity of cardiac conduction system, shorten the refractory period of sinoatrial node. ③ To correct the shock state of low blood output and severe vasoconstriction, the peripheral blood vessels were dilated and the load of heart (especially left heart) was reduced. Pharmacokinetics: atomization inhalation absorption complete, inhalation 2 ~ 5 minutes to take effect, the effect can maintain 0.5 ~ 2 hours. The effect of intravenous injection lasted less than 1 hour; Sublingual administration took effect for 15-30 minutes and lasted for 1-2 hours. After intravenous injection, it acts on β 1 adrenoceptor, half-life is only 1 minute, half-life α 4 minutes. It is mainly metabolized in liver and excreted by kidney. About 5-10% of them were discharged in the original form after atomization inhalation; About 40-50% of them were discharged in the original form after intravenous injection.

Third: the effect on blood pressure: subcutaneous injection (0.5-1 mg) or low concentration intravenous drip (10 mg per minute) μ g) The systolic blood pressure rises because of the increase of cardiac output due to the excitation of viscera; Because the effect of skeletal muscle vasodilation on blood pressure offsets or exceeds the effect of skin mucosa vasoconstriction, the diastolic blood pressure remains unchanged or decreases; At this time, the blood of all parts of the body is redistributed, which makes it more suitable for the needs of the body's energy supply in an emergency. The systolic blood pressure and diastolic blood pressure were increased when a large dose was given intravenously. In addition, epinephrine can also affect the growth of adjacent glomerular cells β 1 receptor, promote the secretion of renin.

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How does isoproterenol affect blood pressure? I'll introduce it to you here. I don't know how much you know about it. I hope you can know more about it. It's helpful for our own health. You know a lot, so I'm here and I hope you are healthy!