What is the reason for high globulin

summary

Globulin mainly refers to serum globulin, which is produced by lymphocytes. Globulin is a simple protein that can be precipitated by 50% ammonium sulfate solution. This substance is insoluble in pure water, but easily soluble in dilute brine, acid or lye. It precipitates or coagulates when heated, and exists in human cells and body fluids. When the liver function is damaged, the globulin will be on the high side. What's the reason for high globulin.

What is the reason for high globulin

First: globulin has immune function. When the liver of patients with liver disease is inflamed, the immune system of the human body will be activated, and the immunoglobulin of the human body will increase, resulting in the high level of globulin. Globulin can be divided into A1, A2, β and γ.

Second, the determination of a 1 globulin has reference value in judging the severity and prognosis of hepatitis. When there is inflammation in the liver, A1 globulin increases, and the increase of A1 indicates that the disease is mild. If the decrease often indicates that the disease is more severe.

Third, a 2 globulin can also reflect the severity of hepatitis. In the early stage of viral hepatitis, most of them maintain normal value, and then gradually increase. In severe hepatitis, if A2 globulin is reduced to less than 0.4 g%, it indicates that the patient will or has been in hepatic coma. In the presence of HCC, a 2 globulin tends to increase. A2 contains lipoprotein. When cholestasis, especially in chronic cases, A2 globulin increases with the increase of blood lipid.

matters needing attention

Gamma globulin is increased in almost all hepatobiliary diseases. In viral hepatitis, the level of α - globulin is moderately increased, and it is expected to recover within 2-3 months.