Symptoms of Guillain Barre syndrome?

summary

Guillain Barre syndrome (GBS) is an autoimmune peripheral neuropathy characterized by demyelinating lesions of peripheral nerves and nerve roots and inflammatory cell infiltration of small vessels. The classic type of GBS is called acute inflammatory demyelinating polyneuropathy (AIDP), The clinical manifestation was acute symmetrical flaccid paralysis.

Symptoms of Guillain Barre syndrome?

Most patients may have gastrointestinal or respiratory tract infection symptoms or vaccination history 1-4 weeks before onset. Acute or subacute onset; The first symptom is myasthenia, more than a few days to 2 weeks to develop to the peak, the common type is ascending paralysis, first appeared symmetrical weakness of both legs, typically in a few hours or just a few days later, from the lower limbs to the trunk, upper limbs or involving the brain nerve.

The lower limbs are more likely to be affected than the upper limbs. The limbs are flaccid paralysis, and the tendon reflex decreases or disappears. Usually, the tendon reflex disappears within a few days in the early stage of the disease. Some patients have mild muscle atrophy, and disuse muscle atrophy may appear in long-term bedridden patients. Except for a few recurrent cases, all types of AIDP patients showed monophasic course, and most of them began to recover at 4 weeks after onset.

Sensory disturbance is generally lighter than dyskinesia. It is manifested as paresthesia of the distal limb, such as burning, numbness, tingling and discomfort, and glove sock like hypoesthesia. It can occur before paralysis or at the same time, or without sensory disturbance.

matters needing attention

This disease is an infectious disease of virus infection of central nervous system which has been declared to be eliminated in the world. It mainly invades motor neurons in the anterior horn of spinal cord. Severe cases may also have quadriplegia or respiratory muscle paralysis. But this disease is different from GBS: paralysis is asymmetric, or only invades a limb or a muscle group; There were no sensory symptoms and signs. There was no cell separation of CSF protein; Electrophysiological examination showed no peripheral nerve damage.