How does cutaneous leucocyte crush sex vasculitis do?
summary
Cutaneous leucoclastic vasculitis is a kind of vascular inflammatory disease that only involves the skin caused by a variety of reasons. How does cutaneous leucocyte crush sex vasculitis do? We have recommended the following information for your reference.
How does cutaneous leucocyte crush sex vasculitis do?
There are many causes of this disease, in addition to idiopathic, mainly related to the following factors. 1. Infection, bacteria (Streptococcus, tuberculosis, leprosy, etc.), viruses (influenza virus, hepatitis B and C virus, Epstein Barr virus), fungi (Candida), protozoa (Plasmodium, Trypanosoma), worms (Schistosoma japonicum), etc. 2. The application of drugs, penicillin, sulfonamides and aspirin can induce the occurrence of the disease. Naproxen and methotrexate can also cause the disease. In addition, heterologous protein serum and insecticide can also be the cause of the disease. 3. Immune abnormalities, patients may have cryoglobulin, high gamma globulinemia.
There may be irregular fever, myalgia and arthralgia. Most of the skin lesions were distributed in the lower limbs, especially in the lower legs and dorsum of the feet. Sometimes thighs, buttocks, trunk and upper limbs can also appear. The lesions are various and may appear in batches in the acute stage. Purpura ecchymosis is the most common, characteristic, often higher than the skin, pressure does not fade. May have the wind mass like erythema, when serious has the blister, the blood blister. Pustules may also appear when neutrophils exudate into surrounding tissues. Sometimes there are subcutaneous nodules of different sizes. If the vascular endothelium is damaged, leading to lumen stenosis, local ulcer and necrosis may occur. Reticular plaques were occasionally seen. Skin rash sometimes accompanied by itching or pain, generally lasting 2 to 4 weeks, after absorption can have pigmentation or left atrophic scars.
The white blood cell count was normal and sometimes increased; Platelets decreased and ESR increased in acute rash stage; Serum complement was decreased. Cryoglobulin and anticardiolipin antibody were detected in some patients. According to the characteristics of young adults, we should consider the diagnosis of polymorphous skin lesions on the lower leg and dorsum of foot, especially palpable purpura like rash.
matters needing attention
Treatment 1. Glucocorticoid, glucocorticoid in acute stage can control symptoms and stabilize the condition. Such as prednisone. 2. In addition, colchicine is effective in some cases, and dapsone and Tripterygium wilfordii preparations can also be used. NSAIDs are used to relieve joint and muscle symptoms. Enteric coated aspirin and dipyridamole (dipyridamole) can be used for anticoagulant therapy.
