What are the causes of localized pleural mesothelioma?

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Localized pleural mesothelioma used to be called benign mesothelioma, but now it is called localized fibroma or localized mesothelioma. The origin of these tumor cells is not clear, the tumor may rise to the subpleural tissue, but some people think that chicken skin cells are the source of this kind of tumor, there is a hypothesis that malignant or benign pleural mesothelioma are derived from a variety of potential cells in the subcutaneous connective tissue, or may develop from mesothelial cells on the surface of the nucleus.

What are the causes of localized pleural mesothelioma?

1. The reason of its pathogenesis is that the limited type of pleural mesothelioma cells are derived from immature stromal cells, which exist in the loose connective tissue under the mesothelial layer of pleura, not from the cocoon cells of pleura. Therefore, it is considered that the best ranking is the localized benign fibroma of pleura.

2. There is indirect evidence that patients with this disease have no history of asbestos exposure, which is significantly different from diffuse malignant mesothelioma. More than 60% of patients with diffuse malignant mesothelioma have a history of asbestos exposure. Most of them are benign, with potential malignancy, 30%, and one with pleural effusion is easy to relapse.

3. The vast majority of benign localized pleurofibromas are located in visceral pleura or interlobar pleura. They grow slowly in nodular shape, protruding into the pleural cavity and growing with pedicles. There are also cases with or without pedicles and attaching to the surface of pleura, which are uncommon in the lung parenchyma. However, only a few of blft in lung were related to pleura, most of them were interstitial cells in interlobular septum.

matters needing attention

Benign pleural mesothelioma is a yellow stemlike tumor with a capsule printed on its location. There are many blood vessels on its surface, mainly veins. Sometimes, the tumor locally invades the lung and chest wall. 70% of benign pleural mesothelioma is located in Changzhi visceral layer, while 30% is located in the parietal layer. The microscopic features are uniform elongation, spindle cells and various numbers of glial and reticular fibrous structures.