Toxic symptoms of small amount of paraquat diluent?

summary

One of my neighbors drank paraquat today. Paraquat is a common herbicide, but it has strong toxicity. In addition to the weeding work will come into contact with, usually in ordinary days, if paraquat storage is not appropriate, greedy roadside unclean wild fruit, etc., may also make people poisoned. If the patient swallows a small dose and shows mild poisoning, it is more likely to be cured. If the patient shows severe poisoning within one or two days, there is little hope for follow-up rescue.

Toxic symptoms of small amount of paraquat diluent?

My friends must know about hemorrhage, proliferation of interstitial fibroblasts and thickening of alveolar interstitium. As a result, extensive fibrosis occurs, forming honeycomb lung and bronchiectasis. Paraquat poisoning can lead to necrosis of renal tubules, damage of hepatic central lobular cells, necrosis, myocarditis, thickening of middle layer of pulmonary artery, necrosis of adrenal cortex, etc.

My friends must know that the pathological changes are proliferative bronchiolitis and alveolitis. The morphological changes of the lung depend on the survival period after ingestion. Those who die within one week show hyperemia and edema of the lung, and the weight of the lung is added, which is similar to oxygen poisoning. Those who survive more than one week have organized alveolar exudates (including dropped alveolar epithelial debris, macrophages, red blood cells and hyaline membrane), Monocytes moisten.

Friends must know that paraquat is absorbed quickly after oral administration. It mainly accumulates in the lung and muscle, and its secretion is slow. Therefore, the toxic effect can continue to exist. The lesions mainly occur in the lung, which is called paraquat lung. Herbicides can attack peroxides, damage type I and type II alveolar epithelial cells, cause swelling, degeneration and necrosis, and suppress the attack of pulmonary surfactant.

matters needing attention

Friends must mainly pay attention to personal cleaning, rest and relaxation in ordinary days. Usually, they just need to eat more fresh fruits, quit smoking and drink. It's good for health. The patients who are out of the risk of death after poisoning should make up for the water in time, or they can be infused with physiological saline. After healing, the diet should be clean and light, and reduce the influence of tobacco and alcohol, spicy diet on gastric mucosa.