How does liver function failure do?

summary

Liver failure occurs in the process of many serious liver diseases, the symptoms are dangerous, causing serious damage to people's body, next I will share how to do liver failure?. Hope to help you.

How does liver function failure do?

First: etiological treatment: for patients with HBV markers and HBV DNA positive liver failure, nucleoside analogues such as lamivudine, telbivudine and entecavir should be used as early as possible on the basis of informed consent. Clinical studies have shown that active and effective antiviral treatment can inhibit virus replication, inhibit the inflammatory process of liver failure in the short term, and inhibit the inflammatory attack in the long term, Delay liver fibrosis and reduce the incidence of liver cancer; However, we should pay attention to the possibility of virus mutation in the follow-up treatment and aggravation after drug withdrawal. For drug or alcohol-induced liver failure, timely discontinuation of suspected drugs and strict abstinence.

Second: hormone therapy: studies have shown that glucocorticoid has a significant effect on reducing the mortality of acute liver failure (especially alcoholic liver failure), but the application of glucocorticoid in patients with HBV induced acute on chronic liver failure is controversial. Zhou Xianshan et al. Found that glucocorticoid (dexamethasone 10mg / D) was used on the basis of antiviral therapy through a randomized grouping study of 63 patients with early chronic severe hepatitis B / ACLF × The total course of treatment (7 weeks) can effectively improve the clinical symptoms, total bilirubin and prothrombin activity, without increasing the incidence of abdominal infection, gastrointestinal bleeding and other complications. We used 30 patients with hbv-aclf as the treatment group and 26 patients as the control group. The results showed that hormone can improve the prognosis of patients.

Third: nutritional support and treatment of promoting hepatocyte regeneration: in order to reduce hepatocyte necrosis and promote hepatocyte regeneration, drugs such as hepatocyte growth promoting factor and prostaglandin El (Peg1) liposome can be used as appropriate, but the efficacy needs to be further confirmed. It should be emphasized that the key to liver regeneration and mortality reduction is to provide the necessary amount and balanced nutritional substrate. In recent years, our research suggests that: low metabolic state of patients with liver failure is not only the self-protection mechanism of the body, but also has a high survival rate. In critical period of the disease, basic metabolic needs can be guaranteed, too high glucose input and too much energy are not conducive to the recovery of the disease. In addition, nutrition intake through gastrointestinal tract is advocated in any stage of disease, and the insufficient part is given intravenously.

matters needing attention

In addition, there may be secondary infection, hepatorenal syndrome, shock and other serious complications. Chronic liver failure occurs on the basis of chronic active liver disease, generally with various manifestations of the original chronic liver disease, can gradually occur liver failure. In the course of the disease, signs of liver failure may suddenly appear due to some liver damage factors.