Symptoms of fluoxetine poisoning?

Update Date: 2024-01-25 Source: Network

summary

Fluoxetine, a selective 5-HT reuptake inhibitor (SSRI), is widely used in clinic. It can selectively inhibit 5-HT transporter, block presynaptic membrane reuptake of 5-HT, prolong and increase the effect of 5-HT, and produce antidepressant effect. It has low affinity for adrenergic, histaminergic and cholinergic receptors and weak effect, so it has less adverse reactions. Oral absorption is good, bioavailability is 70%, easy to pass through the blood-brain barrier, and a small amount can be secreted into milk. In liver, it is metabolized by CYP2D6 to produce mefloxacin, which also has antidepressant effect. Symptoms of fluoxetine poisoning? Let's talk about it

Symptoms of fluoxetine poisoning?

1. The main manifestations of mild poisoning are headache, dizziness, nausea, vomiting, excitation or inhibition of the central nervous system, illusion, loss of time and space sense. Severe poisoning patients may appear coma, respiratory depression, convulsion, closed teeth, angle arch, pupil narrowing, such as needle size and dyspnea and other symptoms.

Nervous system toxicity: most of them have numbness of mouth and whole body, dizziness, fatigue, blurred vision, restlessness and other symptoms. In severe cases, they may have convulsions, drowsiness, unconsciousness or coma. The causes of this reaction are sleeping pills, antipsychotics, antiepileptics, bitter almonds, ginkgo, etc.

Digestive system toxicity: there are abdominal discomfort, nausea, vomiting, abdominal pain, diarrhea, unexplained gastric bleeding, black stool, liver pain, etc. Drugs causing this reaction include aspirin, digitalis, reserpine, fish gall, peach kernel, etc.

matters needing attention

Popularize the knowledge of poisoning prevention and first aid. Strictly abide by the protection and management system of poisons, strengthen the storage of poisons, and prevent the leakage of poisons. The containers of drugs and chemicals should be labeled separately, and the hospital medication should be strictly checked to avoid misuse or overdose.