What are the causes of thalassemia? Analysis of several reasons

summary

Thalassemia is the most common chronic hemolytic anemia in the population. It is a kind of "preventable and refractory" genetic disease. If you can clearly understand your genetic background before marriage, and do a good job in prenatal screening and diagnosis of thalassemia, you can effectively reduce the chance of the next generation suffering from severe thalassemia to the minimum. Let's talk about the causes of thalassemia.

What are the causes of thalassemia? Analysis of several reasons

First, thalassemia is caused by deletion or point mutation of globin gene. There are four kinds of peptide chains in globin, namely α, β, γ and δ chains, which are encoded by their corresponding genes respectively. The deletion or point mutation of these genes can cause the synthesis disorder of various peptide chains, resulting in the change of hemoglobin composition.

Second, due to a variety of mutations in the tissue and structure of globin gene, partial (a), less (a), or complete (a), P liver disorders occur in gene expression, resulting in one or more normal globin chain synthesis reduction or absence, resulting in ~ group high heterogeneity syndrome. The clinical manifestations of different types of thalassemia vary greatly. The most severe cases may die before the birth of the fetus, and the least severe cases may be asymptomatic without anemia for life. Most of the clinical findings are in between the two anemia patients, with low pigment small red blood cells and target red blood cells, and a variety of changes in hemoglobin composition.

Third: the disease is mostly the onset of infants, anemia, weakness, abdominal caking. Most of them are severe dysplasia and often die before adulthood. Mild and intermediate patients can live to adulthood and take part in labor. If we pay attention to labor saving and daily life, we can reduce complications and improve symptoms.

matters needing attention

For mild patients must pay attention to daily medication safety, general cold can not use oxidizing drugs, and to protect the respiratory tract, do not appear the symptoms of infection. It may be that the infection of ordinary people is very common, but the patients with thalassemia are hard to bear. In addition, diet, mood method also need to pay attention to.