What is primary hyperlipidemia?

summary

Primary hyperlipidemia refers to the congenital defect of lipid and lipoprotein metabolism (familial) and some environmental factors, which are caused by various mechanisms. These environmental factors include diet and drugs. Heredity can cause hyperlipidemia through a variety of mechanisms, some of which may occur at the cellular level. What is primary hyperlipidemia? Let's talk about it

What is primary hyperlipidemia?

Familial hypercholesterolemia, the most common type of hypercholesterolemia in children, is an autosomal dominant inheritance β Lipoproteins can not be ingested into cells for normal degradation, resulting in metabolic disorders.

Homozygous patients are often in the skin after birth or childhood β、 Nodular xanthoma of tendon, coronary arteriosclerosis symptoms within 10 years old, and progressive aggravation, the prognosis is often poor. Heterozygous patients may be asymptomatic in childhood. A few of them have nodular xanthoma and lipokeratitis. In adulthood, xanthoma is common, accompanied by coronary atherosclerotic heart disease.

The plasma was clear, the blood cholesterol was high, the triglyceride was normal or slightly high β Lipoprotein increased. It is generally considered that children's blood cholesterol more than 6.24mmol/l (240mg / dl) can be regarded as abnormal.

matters needing attention

The main treatment is diet control. On the premise of sufficient protein and heat energy, the amount of fat should be limited to about 20% of the heat energy. If necessary, antihyperlipidemic drugs should be added, such as cholesterin, nicotinic acid, clofibrate, aminosalicylic acid, etc.