What kind of disease is hyperlipoproteinemia type III?

summary

Type III of hyperlipoproteinemia is also called hyperlipoproteinemia β- Dyslipidemia. LDL is an independent disease, accompanied by VLDLs decomposition and metabolic disorders, leading to the accumulation of LDL precursors and intermediates, the main cause of the disease is due to β- Lipoprotein is higher than normal in serum. Therefore, it can lead to the metabolic decomposition and disorder of some lipid types of lipoprotein in the blood, and then the occurrence of excessive lipoprotein, diabetes or drinking or further damage to lipoprotein clearance.

What kind of disease is hyperlipoproteinemia type III?

The main clinical manifestations are palmar linear xanthoma and nodular xanthoma, nodular xanthoma, maculoma and chorioxanthoma, accounting for about 20% - 30% of the disease. Coronary or peripheral vascular disease often occurs, many patients also have the performance of latent diabetes, serum turbidity, cholesterol and triglyceride levels increased. Serum, cholesterol and triglyceride have considerable volatility.

At present, it is believed that type III hyperlipoproteinemia is caused by many factors. In addition to the abnormal variation of apoE, it is often necessary to combine other genetic or environmental factors. Because of the abnormality of apoE, the metabolism of apoE containing lipoproteins is impaired, while other genetic or environmental factors may increase the synthesis of triglyceride rich lipoproteins. If both exist at the same time, it will produce obvious hyperlipoproteinemia.

In the observation of a large number of patients with type III hyperlipoproteinemia, 43% of the patients had peripheral vascular disease, and about 1 / 3 of the patients had established coronary heart disease. The age of male patients with vascular involvement (mean 40 years) was earlier than that of female patients (mean 50 years). It is generally believed that patients with type III hyperlipoproteinemia have a high risk of atherosclerosis if their plasma cholesterol level is significantly increased.

matters needing attention

The most important thing is to maintain a healthy diet, mainly light diet, do not eat animal viscera; Secondly, proper exercise is very important; Finally, if the effect of reexamination is still not ideal after one month, then it is necessary to combine lipid-lowering drugs, such as Bates and statins; As overweight and hyperlipidemia are important factors of many cardiovascular and cerebrovascular diseases, active intervention is recommended.