Long term proteinuria

summary

A 21-year-old girl with cervical spondylosis found that her urine protein was three plus in a urine test, and then she went to the test many times, ranging from one to three plus. After treatment is now good, I put the long-term urinary protein consequences sorted out for your reference.

Long term proteinuria

Hazard 1: urine protein has toxic effect on glomerular mesangial cells. After patients enter renal failure, there will be a large number of plasma protein deposition in glomerular mesangial area. The deposition of these macromolecular substances in mesangial area can cause mesangial cell damage, mesangial cell proliferation and mesangial matrix formation increase, leading to glomerulosclerosis.

Harm 3: urine protein can damage the renal tubulointerstitium. A small amount of small molecular protein filtered by normal glomerulus is reabsorbed by epithelial cells close to renal tubules and decomposed in lysosomes. Under pathological condition, the increase of glomerular permeability makes a large amount of plasma protein leak into the renal tubules, and the excessive reabsorption of albumin by proximal renal tubular epithelial cells leads to the increase of lysosomal activity in the cytoplasm, which can cause cell damage.

Harm 3: a large amount of proteinuria can increase the protein reabsorption of renal tubules, promote the production of ammonia, and the production of ammonia in renal tissue also plays a role in progressive interstitial lesions. In addition, it needs extra energy to reabsorb and digest a large amount of protein, which can cause tubular cell hypoxia, increase the production of oxygen free radicals and cause tubular cell damage.

matters needing attention

Warm reminder: at present, the recognized risk factors of diabetic nephropathy include hyperglycemia, hypertension, high cholesterol, proteinuria, high protein diet, smoking, family history of nephropathy and obesity. Among them, diabetic proteinuria is the primary risk factor of diabetic nephropathy. The amount and duration of diabetic proteinuria will greatly affect the prognosis.