What is pemphigus

summary

Pemphigus is an autoimmune skin disease, which has many types and needs to be treated symptomatically. Let's see what pemphigus is.

What is pemphigus

First of all: pemphigus is a chronic, recurrent, severe intraepidermal acantholysis bullous skin disease. There are antibodies against cadherin, a CA [sup] 2 + [/ sup] dependent intercellular adhesion molecule, in the patients. Therefore, there are relaxant blisters on the normal skin or mucosa, and Nissl sign is positive.

Secondly, the etiology of the disease has not been completely clear, now it is considered to be an autoimmune disease. The main antigen of pemphigus is desmosomes, and the main antibody is IgG. There are four kinds of IgG subtypes, and a few are IgA. The antibody binds to the epidermal cells, leading to the release of the prickles. The cDNA sequence of pemphigus antigen has obvious homology with cadherin, so pemphigus antibody also damages the adhesion function between epidermal cells, leading to the release of prickles.

Finally, the age of onset is quite different. The average age of onset is 50~60 years. Incidence rate of male and female is similar. In China, pemphigus is traditionally divided into four types: common type, proliferative type, deciduous type and erythema type. After getting sick, we need to make clear our own condition and carry out targeted treatment.

matters needing attention

Patients should be given a low salt, low sugar, high protein, high vitamin diet, pay attention to the balance of water and electrolyte, and intravenous fluid supplement if necessary. In the treatment of patients, whether it is dressing change, or turn over, try to be gentle.