Primary thrombocythemia in the elderly?

summary

Primary thrombocythemia is a clonal disease characterized by abnormal proliferation of megakaryocytes and abnormal morphology and function of platelets. The main clinical features were significant and persistent increase of platelets of unknown origin, and the tendency of bleeding and thrombosis. More than half of them had splenomegaly. What's the specific reason of senile primary thrombocytosis? Let's have a look?

Primary thrombocythemia in the elderly?

Primary thrombocytosis in the elderly is a clonal disease characterized by abnormal proliferation of macrophages, which is characterized by increased platelet count and abnormal morphology and function. Guidance Hello, the majority of elderly patients with primary thrombocytosis will have bleeding or thrombosis symptoms, in which bleeding is the most common, such as gum, epistaxis, gastrointestinal bleeding.

Complications included bleeding, mesenteric and splenic embolism, epilepsy and cerebral hemorrhage. Cerebral hemorrhage, commonly known as cerebral hemorrhage, is a kind of "stroke", which is a common serious brain complication in middle-aged and elderly patients with hypertension. Intracerebral hemorrhage refers to the hemorrhage caused by the rupture of blood vessels in the non traumatic brain parenchyma. The most common causes are hypertension, cerebral arteriosclerosis, intracranial vascular malformation, etc. it is often induced by exertion, emotional excitement and other factors, so most of them suddenly attack in activities. Clinically, the incidence of intracerebral hemorrhage is very rapid, mainly manifested as the damage of nervous system such as disturbance of consciousness, limb hemiplegia, aphasia, etc. It is one of the fatal diseases in the middle-aged and old people.

Most patients have symptoms of bleeding and / or thrombosis. Bleeding is the most common, especially gastrointestinal, gingival and nasal bleeding, female patients often have menorrhagia. Ecchymosis and ecchymosis are rare. Most of them are spontaneous or slight trauma, easy to bleed. There are necrosis and / or secondary atrophic lesions in the corresponding parts of thrombosis, and their manifestations are diverse. Arterial thrombosis is more common in limbs, such as intermittent claudication caused by lower limb thrombosis; The peripheral arterial thrombosis of limbs causes finger (toe) pain or gangrene; Mesenteric and splenic embolism presented as acute abdomen. Once there is thrombosis in lung, kidney, brain or adrenal gland, the disease will mutate and even die. About 80% of the patients have obvious splenomegaly, and some patients have no splenomegaly, which may be due to repeated embolism and atrophy. The liver can also be enlarged. Gout is rare. Some patients have no symptoms for a long time.

matters needing attention

Pay attention to the law of life: develop good living habits, such as work and rest on time, ensure enough sleep and rest time (especially for those who have the habit of taking a nap), and strive for moderate and appropriate recreational and sports activities (especially playing mahjong, bridge, bowling, dancing, mountain climbing, race walking, watching TV and surfing the Internet), so as to keep the bowel movement unobstructed and do not try to lift heavy objects.