How to treat paraneoplastic limbic system encephalitis?

summary

Paraneoplastic syndrome (PNS) is the remote effects of systemic cancer in the central nervous system (CNS) and muscle system. When the limbic system is mainly involved, the clinical manifestation is amnesia syndrome. How to treat paraneoplastic limbic system encephalitis? Let's share my experience with you.

How to treat paraneoplastic limbic system encephalitis?

The symptoms of limbic lobe encephalitis can be relieved after primary tumor resection or chemotherapy, and plasma exchange has also been reported to be effective. At present, there is no specific treatment, so the treatment of primary disease is particularly important. Korsakoff syndrome caused by vitamin B1 deficiency should be paid special attention, because cancer patients are often accompanied by severe nutritional deficiency. The application of large amount of vitamin B1 treatment may improve the worsening process of amnesia syndrome.

The primary tumor of limbic encephalitis and brainstem encephalitis is small cell lung cancer or Hodgkin's disease. Malignant thymoma can also cause this disease sometimes. The etiology is not clear, but anti neuronal autoantibodies have been found in other paraneoplastic neurological syndromes.

Amnesia syndrome caused by paraneoplastic limbic system encephalitis is often accompanied by symptoms of damage to other parts, which depends on the damage of nervous system parts outside limbic system, such as cerebellum, medulla oblongata, pyramidal tract and peripheral nerve.

matters needing attention

It is related to the prognosis of systemic tumors that lead to the syndrome; It is also related to the damage scope of limbic system. The prognosis is different. A large amount of vitamin B1 treatment may improve the progression of amnesia syndrome. Early detection, early treatment.