What is the cause of tubular atrophy?

summary

Tubular atrophy: focal segmental glomerulosclerosis (FSGS) is a common primary glomerular disease in children and adults with nephrotic syndrome (NS). Its histopathological feature is glomerular segmental scar with or without foam cell formation and adhesion in glomerular capillaries. What is the cause of tubular atrophy? Let's talk about it

What is the cause of tubular atrophy?

It can be combined with MsPGN. According to domestic statistics, mesangial proliferative glomerulonephritis (mesangial proliferative glomerulonephritis) is the most, followed by focal segmental glomerulosclerosis, mesangial proliferative glomerulonephritis, membranous nephropathy, etc.

Segmental: one or more glomerulosclerosis, the other glomeruli are normal; Focal: partial glomerulosclerosis in one glomerulus; Most of them were accompanied with renal tubular atrophy and renal interstitial fibrosis; It can be combined with MCD; When the plasma albumin concentration is lower than 20g / L, it indicates that hypercoagulable state exists, that is, preventive anticoagulation therapy should be started.

The disease mostly occurs in children and adolescents, male slightly more than female. A few patients had upper respiratory tract infection or allergic reaction before onset. Nephrotic syndrome is the most common clinical first symptom, about 2 / 3 of the patients have a lot of proteinuria and severe edema, urinary protein can be in 1 ~ 30g / D, about 50% of the patients have hematuria, microscopic hematuria, occasionally gross hematuria.

matters needing attention

In order to prevent diseases, we should avoid fatigue, eat reasonably, exercise scientifically, strengthen physique and improve immunity. For the patients who have already suffered and have complications, we should actively and effectively prevent and treat the primary diseases and complications. If infection is found, antibiotics sensitive to pathogenic bacteria, powerful and non nephrotoxic should be used in time. Those with definite infection focus should be removed as soon as possible.