What disease is gestational trophoblast?

summary

Gestational trophoblastic disease (GTD) is a disease derived from placental villous trophoblastic cells. According to histology, it can be divided into hydatidiform mole, invasive hydatidiform mole, choriocarcinoma and placental site trophoblastic tumor. What disease is gestational trophoblast? Let's talk about it

What disease is gestational trophoblast?

The common manifestation of hydatidiform mole is the rapid enlargement of uterus within 10-16 weeks after pregnancy, which is larger than the expected month of pregnancy. Vaginal bleeding, lack of fetal movement, absence of fetal heart sound and severe nausea and vomiting were common. The diagnosis was confirmed by histological examination.

Human chorionic gonadotropin (hCG) is produced by hyperplastic trophoblast tissue, and serum hCG is the most abundant β Subunits（ β- High level of hCG is helpful to diagnose gestational trophoblastic disease. Pelvic ultrasound is helpful in the diagnosis.

Complications of partial or complete hydatidiform mole include intrauterine infection, sepsis, hemorrhage, pregnancy induced hypertension and development of persistent gestational trophoblastic disease. Placental trophoblastic tumors tend to cause hemorrhage due to their location in the muscular layer; It may infiltrate adjacent tissues and occasionally metastasize to distant sites.

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Patients with a history of hydatidiform mole have a 1% risk of recurrence of the next pregnancy. These patients should be diagnosed as normal intrauterine pregnancy by ultrasound examination in the first trimester of pregnancy. Gestational trophoblastic disease does not damage pregnancy and does not increase congenital malformations, abortion, or prenatal or perinatal complications