What is myasthenia gravis?

summary

Myasthenia gravis (mg) is an autoimmune disease caused by transmission dysfunction at the neuromuscular junction. The main clinical manifestations are partial or systemic skeletal muscle weakness and fatigue. The symptoms worsen after activity and relieve after rest. The prevalence rate was 77 to 150/100 million, and the annual incidence rate was 4 to 11/100 million. The prevalence rate of female is higher than that of male, about 3:2. The incidence rate is in all age groups, and most children are 1-5 years old.

What is myasthenia gravis?

The causes of myasthenia gravis can be divided into two categories. One is congenital hereditary, which is rare and has nothing to do with autoimmunity; The second is autoimmune diseases, the most common. The cause of the disease is still unclear, and it is generally believed that it is related to infection, drugs and environmental factors. At the same time, 65% - 80% of myasthenia gravis patients had thymic hyperplasia and 10% - 20% had thymoma.

Myasthenia gravis patients often feel sore eyes or limbs at the beginning of the disease, or blurred vision, easy to fatigue, hot weather or menstrual fatigue. With the development of the disease, the skeletal muscle is obviously tired and weak, which is characterized by the aggravation of muscle weakness after fatigue in the afternoon or evening, and the alleviation after getting up in the morning or resting. This phenomenon is called "light in the morning and heavy in the evening".

Repeat the electrical stimulation. Repetitive electrical nerve stimulation is a common diagnostic method. The amplitude of muscle response potential was recorded by stimulating the motor nerve with electrodes. If the muscle potential gradually declined, the possibility of neuromuscular junction lesion was suggested. Single fiber electromyography. Single fiber EMG is a more sensitive method to detect abnormal neuromuscular junction conduction than repetitive nerve electrical stimulation. Abnormal neuromuscular conduction can be found according to the increase of "tremor" when the repetitive nerve electrical stimulation and clinical symptoms are normal. In all muscle weakness tests, the sensitivity is the highest.

matters needing attention

Traditional Chinese medicine treatment. More and more attention has been paid to the treatment of myasthenia gravis with traditional Chinese medicine. Myasthenia gravis belongs to the category of flaccidity. According to the theory of traditional Chinese medicine, Jianpi Shuji decoction can reduce the side effects of immunosuppressants, protect the treatment of myasthenia gravis, and rebuild the immune function.