What are the symptoms of tropical megaspleen syndrome in children?

Update Date: 2021-08-17 Source: Network

summary

Tropical megaspleen syndrome is also known as tropical megaspleen disease or idiopathic tropical splenomegaly. The main manifestations were chronic megaspleen, accompanied by hepatomegaly, leukopenia and thrombocytopenia, and increased serum IgM and malaria antibody. The disease is a disorder of immunoglobulin metabolism caused by malaria infection. There are genetic factors. What are the symptoms of tropical megaspleen syndrome in children? Let's talk about it

What are the symptoms of tropical megaspleen syndrome in children?

The age range of onset of the disease is about 8-65 years old, rarely before 8 years old. The main clinical manifestations were low fever, anemia (hemoglobin mostly in 60-100g / L), liver and spleen enlargement, especially the latter.

Anemia is mainly due to increased storage of blood cells in the spleen, hypersplenism, increased blood volume, hemodilution and repeated gastrointestinal bleeding, which lead to shorter red blood cell life, but it can be sharply reduced during pregnancy.

Portal hypertension: refers to the portal vein system pressure rise. The portal vein is formed by the confluence of superior mesenteric vein and splenic vein, which leads the blood from gastrointestinal tract, spleen and pancreas to the liver. The portal vein is divided into left and right branches in the porta hepatis, which is segmental distribution in the liver. The blood from the terminal venules and the blood from the hepatic artery converge in the hepatic sinus, and through the hepatic sinus through the hepatic vein into the inferior vena cava.

matters needing attention

Individual prevention refers to the protective measures taken by the residents of the malaria area or the people who enter the malaria area for a short time in order to prevent mosquito bites, prevent disease or reduce clinical symptoms; Group prevention is to prevent the spread of malaria in high malaria areas, epidemic areas or large numbers of people who live in malaria areas for a long time.