What are the symptoms of multiple myeloma

summary

In today's society, more and more people suffer from multiple myeloma, which is a malignant tumor with plasma cell dysplasia. It is a progressive tumor disease. Once multiple myeloma occurs, the harm to patients is unknown, so every patient with multiple myeloma should pay attention to their own health. Then, what are the symptoms of patients with multiple myeloma? Next, I will tell you.

What are the symptoms of multiple myeloma

Symptom 1: [bone disease] myeloma cells infiltrate and secrete osteoclast activating factor, which can lead to osteolytic damage. Bone pain is the main initial symptom in more than 2 / 3 patients, which is common in the chest and back, and aggravates with activity.

Symptom 2: [hypercalcemia] extensive osteolytic lesions, which can cause the increase of blood and urine calcium, manifested as anorexia, nausea, polyuria, thirst, irritability, arrhythmia, and even coma.

Symptom 3: [kidney damage] due to a large number of monoclonal immunoglobulin light chain deposition in renal tubules, hyperviscosity, amyloidosis, myeloma cell infiltration and complicated with pyelonephritis, 50% of the patients have "myeloma nephropathy" at the time of diagnosis, which can be manifested as proteinuria and nephrotic syndrome, but most of them are not accompanied by hypertension.

matters needing attention

The proliferation of myeloma cells in bone marrow and the inhibition of normal hematopoietic function can lead to pancytopenia. At the same time, due to renal insufficiency, decreased erythropoietin, secondary infection, increased plasma volume caused by hyperviscosity caused by M-protein and other factors, almost all patients have varying degrees of anemia.