What is the reason for the short longitudinal groove?
summary
Nephew was only born two days ago. The doctor said that the child's longitudinal groove is short, and everyone in the family takes nephew as a treasure. According to the doctor, everyone is worried about the newborn baby. I want to ask, what's the reason for the short longitudinal groove?
What is the reason for the short longitudinal groove?
Short longitudinal sulcus is a special appearance of digolger syndrome after birth. It is a kind of disease caused by thymus hypoplasia, lack of T lymphocytes in peripheral lymphoid tissue and blood circulation or T cell dysfunction, It is the result of the development defect of the third and fourth pharyngeal cleft sac. It belongs to primary cellular immunodeficiency disease
Most patients with complete DiGeorge died in infancy. Some patients with incomplete DiGeorge spontaneously improved T cell function and had a longer survival time. Vitamin D and calcium preparations should be used for treatment of hypoparathyroidism and hypocalcemia for a long time. In severe cases, fetal thymus tissue can be transplanted to improve immune function, Bone marrow or lymphoid tissue can also be transplanted, but the effect is uncertain
The etiology of this disease is congenital immune deficiency caused by the abnormal development of the first to the sixth pair of pharyngeal sacs in the early embryo. At the 6th to 10th week of the embryo, the thymus, parathyroid gland, part of the face, aortic arch and heart tuberculosis develop from the cell components of the first to the sixth pair of pharyngeal sacs. At the 12th week of pregnancy, the thymus migrates to the chest
matters needing attention
Most patients with complete DiGeorge died in infancy. Some patients with incomplete DiGeorge spontaneously improved T cell function and had a longer survival time. Vitamin D and calcium preparations should be used for treatment of hypoparathyroidism and hypocalcemia for a long time. In severe cases, fetal thymus tissue can be transplanted to improve immune function, Bone marrow or lymphoid tissue can also be transplanted, but the effect is uncertain
