What is congenital polycystic kidney disease

summary

What is congenital polycystic kidney disease? This is undoubtedly the most headache for patients with polycystic kidney disease and their families. Let's answer this question.

What is congenital polycystic kidney disease

First: congenital polycystic kidney disease is a hereditary disease involving bilateral kidneys, which is the most common congenital cystic kidney disease in human body. The incidence rate of congenital polycystic kidney disease is above 1/1000, and the incidence rate is 1/400 - 1/1000.

Second: congenital polycystic kidney is so common in genetic diseases because it follows the rule of autosomal dominant inheritance. Firstly, men and women are equally likely to have the disease; secondly, if one of the parents is ill, their children are 50% likely to get the cyst gene and get the disease; thirdly, if both the father and the mother are ill, their children are 75% likely to get the cyst gene and get the disease; fourthly, if the male and female who are not ill do not carry the cyst gene, their children will not get the cyst gene after mating with the opposite sex without polycystic kidney Fifth, true congenital polycystic kidney disease, which is not inherited by parents and is caused by gene mutation, is extremely rare.

Third: the whole kidney of congenital polycystic kidney can be covered with large and small cysts, and these cysts will gradually grow with age. Over the years, the volume of the kidney increases, the renal parenchyma is compressed, the kidney shrinks, the renal function is damaged, the number of nephrons that can produce urine is greatly reduced, and the kidney slowly loses the function of maintaining normal life, which eventually leads to the occurrence of chronic renal failure and uremia.

matters needing attention

As we all know, the development of any disease has a process of priority, polycystic kidney is no exception. The compensatory function of the kidney is very strong, so when it is interfered by external factors such as cysts or inflammation, the symptoms are often not very obvious, and it will not have a great impact on life, work and study.