What is the purpose of spironolactone test?

summary

Spironolactone test is carried out according to the following principles. Spironolactone has the effect of antagonizing aldosterone's sodium retention and potassium excretion in distal renal tubules. If the dose is sufficient, it can reduce the urinary potassium excretion of patients with aldosteronism, correct hypokalemia, and approach or reach normal serum potassium level; And it can reduce its elevated blood pressure, even to the normal level. Let's share my experience with you.

What is the purpose of spironolactone test?

After taking spironolactone, the serum potassium of patients with aldosteronism increased significantly, approaching or reaching the normal level, and the 24-hour urinary potassium excretion decreased. In some patients with hypernatremia and alkalosis, hypernatremia and alkalosis returned to normal.

Those who are satisfied with the decrease of blood pressure indicate that it is easy to return to normal after operation, while those who are not satisfied with the decrease of blood pressure often indicate that it is not easy to return to normal after operation. This test is helpful to prove the existence of aldosteronism, but can not distinguish primary or secondary aldosteronism. Abnormal results: there are three types of clinical symptoms of aldosteronism.

Hypertension: Patients with hypertension, and appear earlier, often in hypokalemia caused by the syndrome appeared about 4 years before that. Generally, it is moderately elevated, and diastolic blood pressure is obviously elevated. Neuromuscular dysfunction (1) neuromuscular weakness and paralysis: Generally speaking, the lower the blood potassium, the more serious the myopathy. Fatigue, cold, tension, diarrhea, sweating, and taking anokalemic diuretics (such as dihydroketonuria plug and furosemide) can all induce diabetes.

matters needing attention

Unsuitable crowd: temporarily unknown, taboo before examination: pay attention to normal diet, pay attention to normal work and rest, prevent endocrine disorder. Inspection requirements: actively cooperate with the doctor's requirements. On the third day of regular diet, 24-hour urine was collected to check potassium, sodium and chlorine. On the fourth day, blood was collected to check potassium, sodium, chlorine and carbon dioxide binding capacity (or blood gas analysis) as control.