Symptoms of pseudomembranous enteritis?

summary

Pseudomembranous enteritis is an acute necrotizing inflammation of the colon, which is covered with pseudomembranous. This disease is common after antibiotic treatment, so it is an iatrogenic complication. Pseudomembranous enteritis is mainly caused by Clostridium difficile toxin, strain, host and intestinal microflora. Clostridium difficile isolated from the feces of patients with pseudomembranous enteritis can produce cytotoxic toxins and enterotoxic toxins. The former is an important pathogenic factor of pseudomembranous enteritis. Symptoms of pseudomembranous enteritis? Let's talk about it.

Symptoms of pseudomembranous enteritis?

Clostridium difficile is an anaerobic Gram-positive bacterium. It is the pathogen of pseudomembranous enteritis, which can infect the colon and cause diarrhea, fulminant enteritis and even death. At present, there is a lack of routine detection of Clostridium difficile infection in China, and large-scale epidemiological investigation is rare.

Clostridium difficile itself is non-invasive, but toxin A and toxin B produced by Clostridium difficile can inactivate the members of Rho family guanosine triphosphatase, resulting in necrosis of intestinal epithelial cells, loss of intestinal barrier function and neutrophil infiltration.

The human body can be immune to toxin A and B through active or passive immunity, become asymptomatic carriers or recover after treatment, but the immune deficiency can activate dysfunctional neutrophils and produce inflammatory reaction. Intestinal flora imbalance is also associated with the recurrence of pseudomembranous enteritis.

matters needing attention

? Mild to moderate pseudomembranous enteritis: discontinuation of antibiotics or oral administration of metronidazole 500 mg, 3 times a day, 10-14 days.? Severe pseudomembranous enteritis: oral vancomycin 125 mg, 4 times a day, 10-14 days.? The patients with high risk of recurrence can take oral feldamycin 200mg twice a day for 10 days..? With complications (such as hypotension, intestinal obstruction): vancomycin and metronidazole can be combined.