What is the purpose of cerebrospinal fluid immunoglobulin test?
summary
The main source of CSF immunoglobulin: local synthesis, activated immune cells in central nervous system infection. ② The change of blood-brain barrier makes immunoglobulin in blood enter into cerebrospinal fluid through the increase of capillary permeability. What is the purpose of cerebrospinal fluid immunoglobulin test? Next, I'd like to share my views with you.
What is the purpose of cerebrospinal fluid immunoglobulin test?
IgG was found in subacute sclerosing panencephalitis, multiple sclerosis, acute purulent meningitis, tuberculous meningitis, post vaccination encephalitis, measles encephalitis, neurosyphilis, acute viral meningitis, spinal cord obstruction, systemic lupus erythematosus, gigantism, Arnold child malformation, etc.
IgA was found in cerebrovascular diseases, degenerative diseases, Jacob Greutzfeldt disease, suppurative, tuberculous meningitis and neurosyphilis. IgM indicates central nervous system infection, such as > 30mg / L indicates bacterial meningitis rather than viral meningitis.
Multiple sclerosis, tumor, vascular permeability change, trypanosomiasis and so on can also be increased. The concentration of IgM increased significantly, which was the characteristic of acute purulent meningitis (43.0%) ± 58.0mg/L。 Mild elevation of IgM is the characteristic of acute viral meningitis, IgM is generally 5.0 ± 8 mg / L. if IgM is more than 30 mg / L, the possibility of virus infection can be ruled out.
matters needing attention
Before examination: stop taking drugs. Check: relax the body, eliminate tension and anxiety. If there is obvious edema of optic papilla or aura of cerebral hernia, puncture is contraindicated. Puncture is contraindicated in patients with shock, failure or endangered state, local skin inflammation and space occupying lesions in posterior cranial fossa.
