Does chronic lymphoblastic leukemia need no treatment in early stage?

summary

Chronic lymphocytic leukemia (CLL) is the most common senile leukemia in European and American countries. With the prolongation of life expectancy and the acceleration of aging process in China, the incidence of CLL in China is also increasing. Let's talk about the early stage of chronic lymphoblastic leukemia without treatment?.

Does chronic lymphoblastic leukemia need no treatment in early stage?

First, once a patient is diagnosed with CLL, he will undoubtedly face a series of problems. In fact, as a highly heterogeneous chronic lymphoblastic leukemia, not only patients without medical background have many questions, but even many hematologists often face many puzzles. Because it is also diagnosed as CLL, the development speed, the survival time of patients and the effect of treatment vary greatly. In order to guide and standardize the diagnosis and treatment of chronic lymphocytic leukemia (CLL) and improve the understanding and diagnosis and treatment level of Chinese doctors on CLL, the "guidelines for the diagnosis and treatment of CLL / SLL in China (2015 Revised Edition)" was officially released recently, which was discussed and revised by nearly 40 authoritative hematology experts in China.

Second: chronic lymphocytic leukemia is an senile disease with a median age of 65 years. It is characterized by malignant proliferation of mature lymphocytes, mainly involving bone marrow, peripheral blood, spleen, lymph nodes and other hematopoietic and lymphoid organs. Because it involves peripheral blood, routine physical examination can initially find the disease. Of course, lymphocytic rise is not necessarily chronic lymphocytic disease, other lymphoproliferative diseases are usually manifested as peripheral blood mature lymphocytes rise, so it is suspected that chronic lymphocytic disease must be diagnosed in a professional hospital.

Third, the revised guidelines provide clear guidance and norms from the definition, diagnosis, prognostic factors, treatment indications, treatment options and other aspects of CLL. From the guidelines, we can see that not all CLL patients need immediate treatment. Only when the disease progresses to a certain stage and has certain indications can we give treatment. Because early treatment can not benefit patients, which is different from the general idea of "early detection and early treatment". In the selection of treatment options, it is necessary to consider the cytogenetic characteristics of leukemia cells, the age, physical status and economic status of patients and other factors, and select from the recommended treatment options in order of priority. In order to improve the curative effect as much as possible and reduce the side effects, the classification and stratification treatment strategy fully considers the characteristics of different patients.

matters needing attention

The guideline is based on many foreign related guidelines and consensus, combined with the recent research progress of CLL and the characteristics of patients in China, drug supply and other factors, and formed after repeated discussion. The publication and promotion of the guidelines will play a positive role in guiding the accurate diagnosis and standardized and reasonable treatment of patients with CLL in China.