Symptoms of drug-induced liver and kidney injury

summary

Recently, ziyao, a 2-month-old baby, was hospitalized for "bronchopneumonia". Surprisingly, ziyao blood test found that liver function and other indicators exceeded the normal value nearly 20 times. Later, experts confirmed that it was the careless parents who caused the trouble - self feeding amoxicillin for 3 days, which made the baby suffer from drug-induced liver injury. Experts remind that children's liver and kidney are underdeveloped, their detoxification and excretion function is poor, and their metabolism speed is slow. Therefore, the use and dosage of antibiotics need to be very careful. Parents especially can't be doctors themselves, and the medication for children should be carried out under the guidance of pediatricians. Let's talk about the symptoms of drug-induced liver and kidney injury.

Symptoms of drug-induced liver and kidney injury

"Drug induced liver injury refers to liver injury caused by drugs and their metabolites." Yu Zihua, chief pediatrician of Fuzhou General Hospital of Nanjing Military Region, said that the liver is the largest metabolic organ of the human body, and most of the drugs usually taken are metabolized by the liver and kidney. When the dosage of drugs is too large or the time is too long, it will cause the accumulation of drugs and metabolites, and then cause direct damage to the liver. The annual incidence rate of drug-induced liver injury is about 14 /10 inhabitants, of whom 12% are hospitalized and 6% are dead.

Pharmacology always pays special attention to the safety of stomach, liver, kidney and other viscera when evaluating the toxic and side effects of a drug. However, if there are adverse reactions in gastrointestinal tract after taking drugs, there are usually self-conscious symptoms, and the toxic and side effects on liver and kidney are not easy to detect. Sometimes it is necessary to draw a conclusion through experimental examination. The etiology of drug-induced liver damage is complex, the clinical manifestations are lack of specificity, and there is no gold standard for diagnosis. The original liver disease may cover up the clinical manifestations of drug-induced liver disease, so it is easy to miss diagnosis and misdiagnosis.

Now the health needs people to store constantly, only pay attention to health preservation and timely detoxification, there is no big problem, Runfeng Jinkang amino acid is an effective nutrient to reduce the occurrence of drug-induced liver injury. Generally, liver function can return to normal after a few days of drug withdrawal. Severe cases need symptomatic treatment and liver protection treatment. Treatment principles include drug withdrawal, detoxification, anti-inflammatory, liver protection, and immunosuppressive agents can be added when necessary.

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