What is the cause of Lai's syndrome in children?

summary

Lai's syndrome is an acute progressive encephalopathy, also known as encephalopathy with visceral steatosis, Reye syndrome, viral encephalopathy syndrome, hepatic massive steatosis acute encephalopathy syndrome, vomiting, hepatic lipidosis, etc. This syndrome is characterized by acute encephalopathy and hepatic steatosis. It was first reported by Australian pediatric pathologist Reye in 1963. What is the cause of Lai's syndrome in children?

What is the cause of Lai's syndrome in children?

The clinical manifestations of the disease can be summarized as "four high, four low and one normal". Four high: ① obvious acute intracranial hypertension; ② The incidence of liver damage was high; ③ Hyperammonemia; ④ The mortality is high. Four low: ① low age group; ② The incidence of jaundice was low; ③ There were few signs of ankylosis after removal of cerebral cortex or brain; ④ Hypoglycemia. One is normal, it is to point to cerebrospinal fluid routine and biochemical examination is normal for many times.

The common viral infection before infection is respiratory tract or digestive tract symptoms. The pathogens may be influenza virus, chickenpox, parainfluenza, enterovirus, E-B virus, etc. But so far there is no evidence that the disease is caused by direct infection of virus.

There is more evidence (such as epidemiology) that the sick children who take salicylate (aspirin) when they are infected with the virus are more likely to develop the disease in the future. It has been proved that it can inhibit mitochondria in many ways. In recent years, the incidence of this disease has declined after the use of salicylic acid has been reduced or stopped in Britain, the United States and other countries. In addition, valproic acid, an antiepileptic drug, can cause the same symptoms as Wright's syndrome.

matters needing attention

The prevention of genetic diseases mainly depends on genetic counseling and prenatal diagnosis, because most of the cases of this syndrome are sporadic, so the development of prenatal diagnosis is not common at present. 1. Prevent infection, especially viral diseases, and do a good job in vaccination. 2. Be careful to use or stop using some drugs. Children with viral infection should stop taking salicylate and be careful to use antiepileptic drug valproic acid. 3. Avoid all kinds of toxins. 4. Do a good job in the prevention and treatment of genetic diseases.