How to transplant bone marrow

summary

A colleague's child was diagnosed with leukemia last year. Recently, he has just been successfully matched and needs bone marrow transplantation. Here's how to do bone marrow transplantation?

How to transplant bone marrow

First of all, bone marrow transplantation (BMT) is the treatment of intravenous injection of normal bone marrow cells from donors to patients with leukemia or aplastic anemia. In addition to bone marrow, hematopoietic stem cells used in bone marrow transplantation can also be obtained by recovering PBSCT or umbilical cord blood from peripheral blood. This is also the most direct and effective surgical treatment, but also a relatively large operation, the cost of operation is relatively high.

Secondly, the choice of recipient and donor: the recipient must have appropriate physical and economic conditions, and the allograft must be matched with human tissue associated antigen (HLA). Collection and preservation of hematopoietic stem cells: in case of allogeneic transplantation, it is necessary to find out the donor with the same HLA matching for the patient to collect stem cells; in case of autotransplantation, it is necessary to collect the stem cells in remission stage before the pretreatment of the patient and keep them in vitro.

Finally, pretreatment before transplantation: the patients were pretreated with high-dose chemotherapy and (or) radiotherapy under full environmental protection after various examinations before transplantation, in order to clear malignant cells or abnormal cell populations in bone marrow, and prepare environment for normal stem cell implantation. Reinfusion of hematopoietic stem cells: intravenous infusion of donor (allogeneic or autologous) hematopoietic stem cell suspension. Prevention and treatment of complications after bone marrow transplantation: prevention and treatment of complications such as graft-versus-host disease (GVHD), infection, hemorrhage, interstitial pneumonia and supportive treatment should be carried out after bone marrow transplantation.

matters needing attention

Bone marrow transplantation is a kind of treatment with stable curative effect, but what we need to pay attention to is the conditioning after operation. We should carry out various conditioning in daily living habits and diet methods, so as to promote the rapid recovery of the body.