The pain of forgetfulness: a special drug for Alzheimer's disease
summary
Alzheimer's disease is harmful to the physical and mental health of the elderly. Alzheimer's disease is the most common, followed by cerebrovascular dementia, and the third is caused by infection, tumor, trauma, etc. Alzheimer's patients with cognitive ability and memory function will continue to deteriorate, gradually daily living ability can not take care of themselves, there will be a variety of neuropsychiatric symptoms and behavioral disorders, the elderly with Alzheimer's need long-term medication, then what are the commonly used drugs for Alzheimer's patients?
The pain of forgetfulness: a special drug for Alzheimer's disease
First: improving choline neurotransmitter drugs: one of the main causes of Alzheimer's disease is choline deficiency, which leads to memory loss, disorientation, behavior and personality changes. Therefore, cholinergic drugs play an important role in the treatment of Alzheimer's disease. At present, four commonly used acetylcholinesterase (AChE) inhibitors are tacrine, Aricept, esnen and galanthamine (the other is N-methyl-D-aspartate (NMDA) receptor antagonist, memantine hydrochloride).
Second: drugs to improve cerebral blood circulation and brain cell metabolism: Alzheimer's patients have metabolic disorders such as sugar, protein, nucleic acid and lipid, and their cerebral blood flow and oxygen consumption are significantly lower than those of normal people of the same age. Therefore, cerebral metabolic activators and cerebral circulation improvers, especially cerebral metabolic activators with cerebral vasodilation, have become a large class of drugs for the treatment of Alzheimer's disease. Such drugs as Naofukang, Dukexi, xidezhen, pentoxifylline, Naotong, etc.
Third: calcium antagonists: these drugs are easy to pass through the blood-brain barrier, selectively dilate cerebral vessels, reduce the damage or death of nerve cells caused by calcium influx, so as to improve memory and cognitive function.
matters needing attention
High dose of muscarinic M1 receptor agonist zhanomelin can significantly improve the cognitive function and motor behavior ability of patients with Alzheimer's disease. However, due to the serious side effects of the drug in gastrointestinal and cardiovascular, many patients can not continue treatment.
