What are the causes of osteoarthritis

summary

Osteoarthritis is a kind of orthopedic disease which seriously endangers human health. I believe everyone knows something about it. But often in life, people do not care about disease prevention, which also brings opportunities for many diseases. So, what are the causes of osteoarthritis?

What are the causes of osteoarthritis

1. Bacterial factors. Experimental studies have shown that group A streptococcus and peptidoglycan may be a continuous stimulant of RA. Group A Streptococcus exists in the body for a long time and becomes a continuous antigen to stimulate the body to produce antibodies and produce immunopathological damage. The animal model of arthritis produced by mycoplasma is similar to human RA, but does not produce the specific rheumatoid arthritis of human RA Rheumatoid factor (RF) has never been found in the synovial fluid and synovial tissue of RA patients, which suggests that bacteria may be related to the onset of RA, but there is no direct evidence, so the cause of rheumatoid arthritis is not very clear.

2. Virus. The relationship between RA and Epstein Barr virus, especially Epstein Barr virus (EBV) is one of the problems that scholars at home and abroad pay attention to. Studies have shown that the arthritis caused by EBV infection is different from RA. RA patients have a strong reaction to EBV than normal people. There are persistent high anti EBV membrane antigen antibodies in the serum and synovial fluid of RA patients, but so far no EBV nuclear antigen or shell antigen has been found in the serum of RA patients Antigen antibody, which is one of the causes of rheumatoid arthritis.

3. Genetic factors. The incidence rate of this disease is higher in some families. In the population survey, it is found that human leukocyte antigen (HLA) -DR4 is positively correlated with RF positive patients. HLA study found that 70%HLA-DW4 positive patients in DW4 patients had the susceptible genes of this point, so heredity might play an important role in the pathogenesis, which is an important factor contributing to the cause of rheumatoid arthritis.

matters needing attention

Through the above knowledge, we have some understanding of the causes of osteoarthritis. I hope everyone can pay attention to these problems, and try to find the prevention methods of osteoarthritis according to the reasons, so as to avoid the injury of the disease. Here to remind the majority of friends have to improve the understanding of osteoarthritis, alert to the occurrence of the disease.