How is brown yellow disease treated?

summary

Ochronosis is caused by the lack of homeostasis oxidase, which makes phenylalanine and tyrosine intermediate metabolites (uromelanic acid) unable to be further oxidized and decomposed and accumulated in the body. Make skin, sclera, cartilage color dark, at the same time, urine black acid cause cartilage and other connective tissue pigmentation, appear degenerative arthritis of the spine and peripheral joints. On the other hand, urine black acid is excreted with urine, which is alkalized and oxidized in urine to make urine turn black, so it is also called alkaptonuria. This disease is a rare genetic disease, rare. It is reported that the prevalence rate is 3-5 cases per million population. Because urine black acid is easy to deposit in cartilage, joint degeneration. But in clinical often appears the joint disease, therefore is called the brown yellow sickness joint disease. Now let's get to know.

How is brown yellow disease treated?

First, the most serious complication of this disease is arthrosis. Different from rheumatoid arthritis, the disease mainly invades the spine, shoulder, hip and other large joints, while sacroiliac, hand and foot joints are rarely involved. In male patients, the onset of the disease is early and severe, the knee joint is the most frequently involved, and the degree of damage is also the most serious. Spinal disease is also the most common bone and joint damage of this disease, often manifested as lower back stiffness and pain. The disease first occurred in the lumbar spine. With the development of the disease, it can affect the thoracic spine, block the spinal movement, and disappear the physiological curvature of the spine. Disc herniation and calcification are also the characteristic manifestations of the disease. The typical patient shows forward duck gait. Synovial fluid is non-inflammatory and mainly contains monocytes. Arthroscopy showed black staining of synovium. After the effusion disappeared, joint contracture could occur gradually.

Second, there is no effective treatment for the disease, so it is unrealistic to limit the intake of phenylalanine and tyrosine in diet to reduce the incidence of urinary melanoaciduria. Taking vitamin C for a long time can inhibit the oxidation and polymerization of urine black acid, which may have certain significance in relieving clinical joint symptoms. For the treatment of joint disease, it is mainly appropriate rest and physical therapy, and analgesic drugs are given when necessary. The patients with joint deformity can be operated as appropriate.

Third: black urine, typical pigmentation of skin and X-ray manifestations of large joints such as spine, shoulder and knee constitute the three major characteristics of brown yellow disease, which can be used for diagnosis. If possible, special examination of urine black acid in blood and urine can be done.

matters needing attention

Should not eat too much contains more phenylalanine and tyrosine food, such as natural protein potato sweet potato. These foods can reduce the level of urine black acid; High dose vitamin C can inhibit the combination of urinary melanin and connective tissue, resist its inhibitory effect on the growth of chondrocytes and prevent morphological deformation and degenerative changes.