Causes of proteinuria 2

summary

When pregnant terminal, went to the hospital to check inside, say is albuminuria is on the high side, successive two months were, improve somewhat now, the reason that aims at albuminuria 2 this problem? Do you want to discuss it together? So let's share the reason for protein2.

Causes of proteinuria 2

Reason 1: mesangial toxicity of proteinuria: in the model of renal failure, the accumulation of serum protein in glomerular mesangium can be observed. The accumulation of these macromolecular substances in mesangial area can cause mesangial cell damage and proliferation, and increase the synthesis of mesangial matrix, resulting in glomerulosclerosis.

Reason 2: the toxic effect of proteinuria on proximal convoluted tubular cells: when proteinuria occurs, the amount of protein entering the epithelial cells of renal tubules increases, which increases the activity of lysosomes, suggesting that protein causes lysosomes to overflow into the cytoplasm of tubular cells, and subsequent cell damage can stimulate inflammation and scar formation.

The third reason: the biological changes of tubular cells caused by proteinuria: many kidney diseases with proteinuria have excessive cell proliferation, which represents a non adaptive response and leads to renal failure. More and more evidences show that proteins can directly regulate the function of tubular cells, change their growth characteristics and the phenotypic expression of cytokines and matrix proteins, which can lead to the release of PDGF, FN and MCP-1 from the basal side of tubular cells and induce fibrosis.

matters needing attention

Warm reminder: eat less plant protein, urine protein 1 + to pay attention to, can not eat too much plant protein, contains a lot of purine base, this material will increase the burden of kidney metabolism, aggravate the patient's condition, so should eat less or not. In addition, soy and soy products, proteinuria patients should also avoid using.