How should breast carcinosarcoma be treated?

summary

Carcinosarcoma of the breast refers to the tumor coexisting cancer and sarcoma in the ipsilateral breast, which is more common in elderly women. Primary breast carcinosarcoma is rare. Breast carcinosarcoma patients with palpable breast mass, often accompanied by axillary lymph node enlargement. How should breast carcinosarcoma be treated? Next, I'd like to share my views with you.

How should breast carcinosarcoma be treated?

Breast carcinosarcoma has two components: cancer and sarcoma. It can be transferred to regional lymph nodes according to the law of cancer metastasis, and it can also have blood metastasis according to the law of sarcoma metastasis. Therefore, the treatment method is the same as breast cancer. Comprehensive treatment should be taken. Radical operation should be performed as soon as possible after diagnosis, and postoperative adjuvant radiotherapy, chemotherapy and other comprehensive treatment should be carried out.

Both components of carcinosarcoma can metastasize, but most of the carcinosarcoma metastasizes to regional lymph nodes, while the sarcoma mainly metastasizes to blood vessels. Generally, axillary lymph node metastasis rate is higher in metastatic breast carcinosarcoma cases, so once the diagnosis is confirmed, radical mastectomy should be the first choice.

Some advocate postoperative radiotherapy if lymph node metastasis. For the patients who can not be operated in the late stage, radiotherapy and chemotherapy or biological therapy should be used as appropriate. Tamoxifen is a non steroidal hormone anti estrogen drug. Its structural formula is similar to that of estrogen. It can compete with estradiol for receptor in target organs. Tamoxifen and estrogen receptor complex can affect DNA gene transcription and inhibit the growth of tumor cells.

matters needing attention

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