The early symptom of lupus nephritis?

summary

Lupus nephritis (LN) refers to systemic lupus erythematosus (SLE) with different pathological types of renal immune damage, which requires patients to maintain enough attention to accept the relevant treatment of this disease, accompanied by obvious clinical manifestations of renal damage. So we must do a good job of the disease related work, then the early symptoms of lupus nephritis?.

The early symptom of lupus nephritis?

First, lupus nephritis is a common secondary glomerular disease in clinic. Its clinical manifestations are diverse and complex, which often lead to misdiagnosis. Some patients with severe disease, rapid development, if not timely diagnosis can quickly develop into renal failure or multiple organ failure, leading to death. The incidence rate of lupus nephritis is high in tropical areas and in coastal areas of southern China. The incidence rate of young women (20-30 years old) is high (male: female = 1:9). As the etiology of SLE is not clear, there is no specific treatment so far. Early diagnosis and treatment can improve the prognosis of SLE. Recently, great progress has been made in the treatment of integrated traditional Chinese and Western medicine, and the prognosis has been significantly improved. For example, due to early correct diagnosis and proper treatment, the 5-10-year survival rate of lupus nephritis increased from 20% - 40% to 74.6-81.1%.

Second: general symptoms: most patients show general fatigue, weight loss, 90% of patients have fever, some can exceed 39 ℃. Skin, mucous membrane damage: most patients have skin damage in the skin exposure, about half of the patients appear butterfly erythema, or hair loss. Some patients can see urticaria, discoid erythema, palms, fingers, nail erythema, purpura and so on. Some patients have oral ulcers. Alopecia was the main index of SLE activity. Joints and muscles: 90% of patients have joint pain, common in small joints of limbs. About 30% of the patients had myalgia. Long term irregular use of hormone can lead to aseptic necrosis of femoral head in some patients. Cardiovascular: some patients may have pericarditis, generally transient and mild, a few patients may have myocarditis. About 1 / 4 of the patients may have Raynaud's phenomenon.

Third: simple hematuria or proteinuria, hematuria, proteinuria with edema, lumbar acid or hypertension, that is nephritis like performance; Large amount of proteinuria, hypoproteinemia, edema, namely nephrotic syndrome like manifestations; Hematuria, albuminuria with renal function decreased rapidly, presenting as rapidly progressive nephritis; Renal interstitial lesions; Chronic renal failure.

matters needing attention

Its pathogenesis is related to the formation of immune complexes, immune cells and cytokines. In addition to systemic manifestations of SLE, the main clinical manifestations were hematuria, proteinuria and renal insufficiency.