What does bone alkaline phosphatase mean?
summary
Many women don't know what bone alkaline phosphatase is. Every time I go to the hospital for examination, I will see this data. What does this data mean? Here is a detailed answer for you.
What does bone alkaline phosphatase mean?
Bone alkaline phosphatase is an extracellular enzyme of osteoblasts. It is a glycoprotein with molecular weight of 12000 Dalton. When the enzyme was synthesized in the cell, the new enzyme protein was glycosylated in the endoplasmic reticulum, then transported to the surface of the cell membrane through Golgi apparatus, and chimerized with phosphoinositide through polysaccharide chain to the outer plasma membrane of the cell membrane.
Under the action of polysaccharide inositol phosphate specific hydrolase, bone alkaline phosphatase can be released into blood circulation. The physiological function of bone alkaline phosphatase is to hydrolyze phosphate ester in the process of osteogenesis and provide necessary phosphate for the deposition of hydroxyapatite; At the same time, the hydrolysis of pyrophosphate can relieve its inhibition on the formation of bone salt, which is conducive to the process of osteogenesis.
With the improvement of the sensitivity and specificity of bone alkaline phosphatase detection methods, bone alkaline phosphatase as a marker of abnormal bone metabolism has been paid more and more attention. Clinical studies have shown that the quantitative determination of serum bone alkaline phosphatase activity can be used as an effective parameter to monitor the changes of bone formation. Similar to most metabolic bone diseases, osteoporosis is a disease with insufficient bone capacity, which is common in postmenopausal women. Insufficient bone volume occurs when the rate of osteolysis is greater than the rate of osteogenesis. Effective treatment requires correction or measurement of bone mineral density, but the change of bone mineral density is too slow to be used as an early response for clinical monitoring of treatment effect.
matters needing attention
As a component of osteoblasts, bone type alkaline phosphatase participates in the process of osteogenesis, and its activity is stable in serum without day and night changes. Therefore, the quantitative determination of serum bone type alkaline phosphatase activity can be used to observe the change rate of bone formation and provide effective monitoring means for clinical treatment. I hope the above information can help you.
