Symptoms of atropine poisoning?

summary

Atropine poisoning is caused by the presence of atropine in several Solanaceae plants, such as belladonna, scopolamine and Datura stramonium. Pure products are white crystals, bitter taste, insoluble in water, its salts are commonly used in medical treatment. Most of the poisoning is due to excessive use of medical atropine sulfate, belladonna extract and belladonna mixture. Children are often poisoned by eating the fruits of such plants (such as stramonium stramonium berries). It is rarely used for suicide or homicide. Occasionally, Solanaceae plants are poisoned or homicide is carried out under the guise of medical treatment. Symptoms of atropine poisoning? I'd like to share my views with you.

Symptoms of atropine poisoning?

Atropine has an excitatory effect on the central nervous system and then turns to inhibition. The oral dose was 5? The lethal dose was 80 mg and 10 mg for children. The lethal blood concentration was 0.02% (mass fraction). Anatomically, the face was flushed and the pupil dilated. Visceral congestion, lung and brain edema. When Solanaceae plants are poisoned, plant residues can be found in the stomach. In the identification, we should pay attention to the signs with diagnostic significance, such as facial flushing, mydriasis, dry mucous membrane and so on, and analyze them in combination with autopsy findings and poison test results.

The heart rate was more than 120 beats / min. ② Body temperature > 39 ℃. ③ The pupil is extremely dilated, even reaching the edge. The patient was conscious or comatose at the time of admission. After the application of atropine, there were delirium, agitation, skin flushing and other atropinization phenomena, but gradually turned into coma until coma. In our retrospective analysis, atropine poisoning generally has this process, but there are a few serious atropine poisoning does not appear the above performance, directly cause central inhibition, namely "atropine turnover phenomenon", which should be paid attention to. ⑤ In the course of atropine application, the poisoning symptoms were relieved for a time, and then reappeared. ⑥ Pulmonary rales were relieved or disappeared, then appeared again, or became worse when atropine was not reduced. When the above two symptoms appear, atropine poisoning is highly suspected and can be diagnosed when there are three or more symptoms.

The effective prevention and treatment methods are as follows: 1) to accurately judge the degree of AOPP and make sure whether atropine has been used before admission, so as to reasonably select the first dose of atropine; ② To master the identification points of atropinization and atropine poisoning; ③ Once atropine poisoning was found, the drug was stopped immediately, and rehydration and diuresis were given; ④ Active prevention and treatment of respiratory failure, circulatory failure, brain edema and metabolic acidosis.

matters needing attention

1. Do a good job in food hygiene supervision and canteen hygiene, and prohibit eating dead livestock meat or other deteriorated meat. Drunk shrimp, pickled crab and so on are best not to eat. 2. Refrigerated food should be of good quality and fresh-keeping, animal food should be thoroughly heated before eating, and leftover food should also be fully heated after every meal. 3. When cooking, separate raw from cooked to avoid cross contamination. 4. Marinated canned food should be boiled for 6-10 minutes before eating. 5. It is forbidden to eat poisonous animals and plants such as toadstools and puffer fish. 6. Cooks and nurseries with Salmonella infection or carrier should be transferred from work, and they can return to their original jobs after three times of stool culture negative.