What is the cause of lactic acid poisoning
summary
Lactic acidosis is one of the complications of diabetes mellitus. If it occurs, if it is not treated in time, the probability of death is very high. Diabetic patients with diarrhea, vomiting, abdominal pain, blurred consciousness, decreased blood pressure, poor breathing symptoms, to the regular hospital as soon as possible to measure blood lactic acid level. If the blood lactic acid concentration is more than 2 mmol / L, it is lactic acidosis. We should find out the cause and treatment as soon as possible. What is the cause of lactic acidosis and how to treat it?
What is the cause of lactic acid poisoning
First: lactic acidosis can be caused by congenital genetic defects, but also by a variety of acquired factors. Lactic acidosis caused by genetic defects is relatively rare, and acquired lactic acidosis is relatively common. There are two common causes of lactic acidosis, one is the mixture of tissue hypoxia (type A) and non tissue hypoxia (type b), the other is tissue hypoxia and non tissue hypoxia.
Second: the decrease of arterial oxygen content: carbon monoxide poisoning and asphyxia are the main reasons for the decrease of arterial oxygen content. In addition, anemia, hypoxemia, arterial oxygen content will also be reduced. 2) Tissue hypoperfusion: hypotension and decreased cardiac output are one of the causes of tissue hypoperfusion. In addition, tissue hypoperfusion may occur in patients with increased vascular permeability.
Third: fructose 1, pyruvate carboxylase deficiency, oxidative phosphorylation deficiency; 2) drugs or toxins: ethanol, methanol, nicotinic acid, catecholamine, isoniazid, streptozosin, cocaine, estrogen deficiency; 3) diseases: diabetes, sepsis, malaria and cholera; 4) others: seizures.
matters needing attention
Lactate / pyruvate ≥ 30 mmol / L, blood pyruvate 0.2-1.5 mmol / L, blood lactate level increased, blood ketone body slightly increased, blood pH value decreased, anion gap expanded, and plasma osmotic pressure was normal.
