Can Pneumocystis carinii be cured?

summary

Pneumocystis carinii is a protozoosis caused by Pneumocystis carinii infection. The main clinical manifestations were dry cough, dyspnea and cyanosis. The pathogen is characterized by interstitial pneumonia, so it is called Pneumocystis carinii pneumonia. This disease is often seen in patients with low immune function or deficiency, which can be regarded as an opportunistic infection. Since 80s, the incidence rate and mortality of AIDS in AIDS patients have been discovered in recent years. The study of Pneumocystis carinii, especially PCP, has gradually deepened. Can Pneumocystis carinii be cured?

Can Pneumocystis carinii be cured?

Pneumocystis carinii is a protozoosis caused by Pneumocystis carinii infection. The pathogen is characterized by interstitial pneumonia, also known as Pneumocystis carinii pneumonia, is a rare pneumonia, is a conditional pulmonary infectious disease, mainly occurs in children with low immunity. It is also the most common pulmonary complication of AIDS patients, or cancer or kidney transplant patients treated with immunosuppressant.

In the treatment of (1) sulfamethoxazole / trimethoprim (compound sulfamethoxazole) is the preferred anti Pneumocystis drug（ 2) Pentamidine is mainly used in patients who have no response to sulfamethoxazole / trimethoprim treatment or are allergic to sulfa drugs. Can have heart, kidney, liver damage, bone marrow suppression, hypoglycemia and other side effects（ 3) Azavaquine, dapsone and other drugs can be used α- Difluoromethylornithine pyrimidine plus sulfadoxine, primaquine plus clindamycin, etc. This early treatment, the cure rate can reach 60 ~ 70%.

Sporadic hair is also known as children adult type. It is more common in patients with low immune function or deficiency. The onset was sudden, fever, cough, dyspnea and cyanosis appeared rapidly, but there were few rales. Patients with short course of disease may die within 4-8 days. Chest X-ray changes are often later than clinical manifestations. If there is no specific treatment, the mortality rate of both adults and children is as high as 90% - 100%. The X-ray findings of the two types of lung were diffuse, bilateral cord or spot shadow. Pneumonia and lung base were less involved. It can develop rapidly and cause pulmonary consolidation. In the consolidation lesions, there are often extensive or limited small segment atelectasis after emphysema. In some cases, pneumothorax, pleural effusion and pulmonary nodule shadow can be seen. The arterial partial pressure of oxygen was often lower than 10.7 kPa (80 mmHg), the partial pressure of C02 was normal or low, and the arterial pH was often increased.

matters needing attention

Patients should be isolated from respiratory tract. Improve the nutritional status of patients, reduce unnecessary immunosuppressive chemotherapy and radiotherapy. For susceptible and high-risk groups, drug prevention can be taken. For example, compound sulfamethoxazole, TMP 5mg / kg per day, SMZ 25mg / kg per day, oral twice, three times a week, course of 5-18 months. It can also be prevented by pentamidine aerosol and dapsone. There is no vaccine available.