The harm of high proteinuria in pregnancy

summary

After the physical examination, the doctor said that my other physical indicators are very normal, that is, the urine protein is a little high, and now it is finally cured. Today I will share with you the harm of high urine protein in pregnancy.

The harm of high proteinuria in pregnancy

Hazard 1: urine protein has toxic effect on glomerular mesangial cells. After patients enter renal failure, there will be a large number of plasma protein deposition in glomerular mesangial area. The deposition of these macromolecular substances in mesangial area can cause mesangial cell damage, mesangial cell proliferation and mesangial matrix formation increase, leading to glomerulosclerosis.

Harm 3: urine protein can damage the renal tubulointerstitium. A small amount of small molecular protein filtered by normal glomerulus is reabsorbed by epithelial cells close to renal tubules and decomposed in lysosomes. Under pathological condition, the increase of glomerular permeability makes a large amount of plasma protein leak into the renal tubules, and the excessive reabsorption of albumin by proximal renal tubular epithelial cells leads to the increase of lysosomal activity in the cytoplasm, which can cause cell damage.

Harm 3: a large amount of proteinuria can increase the protein reabsorption of renal tubules, promote the production of ammonia, and the production of ammonia in renal tissue also plays a role in progressive interstitial lesions. In addition, it needs extra energy to reabsorb and digest a large amount of protein, which can cause tubular cell hypoxia, increase the production of oxygen free radicals and cause tubular cell damage.

matters needing attention

Warm reminder: patients should adopt different standard protein diet according to the types of proteinuria and different conditions. For example, patients with nephritis proteinuria should choose protein food with high physiological value. Patients with severe proteinuria can eat more protein food. Pay attention to supplement trace elements, urinary protein 1 + appear, should pay attention to not lack of protein, so diet to add more calcium, magnesium, zinc and other trace elements, should eat more fresh fruits and vegetables, such as milk, shrimp, kelp, millet, barley, meat and so on.