What are the manifestations of Wegener's granuloma in children?

summary

Wegeners granulomatosis (WG) is a systemic disease characterized by necrotizing and granulomatous vasculitis of upper and lower respiratory tract, glomerulonephritis and vasculitis of other organs. The lesions involved small arteries, veins and capillaries. The clinical manifestations are usually rhinosinusitis, lung disease and progressive renal failure. What are the manifestations of Wegener's granuloma in children? Let's talk about it now.

What are the manifestations of Wegener's granuloma in children?

This disease is characterized by sinusitis, lung infiltration and kidney disease triad. In the early stage of illness, children often have some non-specific systemic symptoms, such as fever, fatigue, weight loss, muscle pain and joint pain. Many children also have seasonal allergies. Upper respiratory tract symptoms followed.

The common respiratory symptoms are rhinitis, sinusitis, nasal obstruction, runny nose and epistaxis, which can invade the nasal septum, even extend to the palate, tongue, pharynx, throat and other parts, resulting in ulcers. When the lung is involved, cough, hemoptysis, etc.

When the kidney is involved, there may be nephritis, proteinuria, hematuria and even renal insufficiency. Ocular lesions include conjunctivitis, scleritis, corneal ulcer, uveitis and exophthalmos. The central nervous system may be affected by intracranial granulomatous lesions and vasculitis, and organic brain syndrome, mental symptoms, hemiblindness, convulsions and hemiplegia may occur. Vasculitis of peripheral nerve can cause peripheral neuritis. Severe cases can also appear rash, joint swelling and pain and splenomegaly.

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The prognosis of this disease is serious. Patients with upper respiratory tract symptoms can survive for a long time, but often leave destructive scars. If early diagnosis, early treatment, early application of adrenocortical hormone combined with immunosuppressive therapy, can prevent the progress of the disease, 5-year survival rate of 95%.