The main symptom of aconitine poisoning?
summary
Aconitine is the main toxic component in Aconitum carmichaeli, Aconitum kusnezoffii and Aconitum carmichaeli. It mainly excites vagus nerve and damages peripheral nerve. The main poisoning symptoms were nervous system and circulatory system, followed by digestive system symptoms. What are the main symptoms of aconitine poisoning.
The main symptom of aconitine poisoning?
The main clinical manifestations are numbness of the tongue and limbs, tight sense of the whole body, etc. it can reduce the automaticity of the sinus node by exciting the vagus nerve, cause the increase of automaticity of the translocation pacemaker, cause arrhythmias and damage the myocardium.
The toxic mechanism of Aconitum carmichaeli is mainly to the nerve and heart. In the nerve aspect, it is the first to excite and paralyze the sensory nerve and central nerve. Some people think that the mechanism of the disappearance of temperature, pain and pressure sensation may be that Aconitum carmichaeli acts directly or indirectly on the unmyelinated and slender nerve fibers, thus preventing the occurrence and transmission of impulses.
Due to the direct effect on the myocardium, the excitation, conduction and refractory period of each part of the myocardium are not consistent, and the repolarization is not synchronous, so it is easy to form reentry, resulting in serious qualitative arrhythmia (including torsade ventricular tachycardia), and even ventricular fibrillation. A large number of facts show that serious arrhythmia is a common cause of death in aconitine poisoning. Aconitine can inhibit the vasomotor center to reduce blood pressure, inhibit or directly inhibit the contraction of the uterus by exciting the vagus nerve. At the same time, the inhibition of vasomotor center and serious arrhythmia lead to the decrease of cardiac output, and frequent vomiting leads to the decrease of blood volume and shock.
matters needing attention
1) Oral or external use of Chinese medicine or medicinal wine containing Aconitum kusnezoffii or Aconitum carmichaeli should be stopped immediately（ 2) Early emesis, gastric lavage and catharsis should be done immediately. Gastric lavage solution can be potassium permanganate and tannic acid solution. Cathartic can be injected sodium sulfate or magnesium sulfate from gastric tube after gastric lavage. 2% saline can also be used for high colon lavage, but if it is medicated wine, gastric lavage is of little significance. (3) large amount of fluid infusion to promote the excretion of poison.
